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In the 5xFAD mouse model of AD, exendin-4 reduced the expression of Drp1 and increased that of OPA1 and Mfn2 [163]
PF-06882961 has shown significant promise in reducing blood glucose levels and body weight in patients with type 2 diabetes
Congenital hyperinsulinism is a heterogeneous condition in regards to genotype and phenotype
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As this region of ORC1 cleaved by X(PC4) variants occurs in a section of the protein predicted to be structured and therefore may be less accessible to a protease, we prioritized eliminating cleavage of IL-1 by performing evolution using dual-selection PANCE with a 25-amino-acid segment from IL-1 as the negative selection substrate, IL-1 (residues 529
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