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This chimeric structure distinguishes them from a separate class of dual- or tri- agonist molecules in which conjugation strategies involving synthetic linker chemistry are used to fuse the full-length amino acid sequences of peptides such as the hormones glucagon, GLP-1, gastrin, and gastric inhibitory polypeptide (GIP) 1,2,3,15

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All statistical analyses were performed using SAS 9.4 (SAS Institute, Inc, Cary, NC), hazard ratios (HR) with 95% confidence interval (CI) were reported, and statistical significance was defined as a p-value of less than 0.05

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