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Due to distinct tissue expression of receptors, MT-2 is incorporated alongside selective antagonists, genetic models, or specific interventions to attribute observed effects to receptor subtypes

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4,5,236,237,238 A 2018 expert panel on cholesterol management, representing numerous cardiology and physician societies, including the American College of Cardiology and American Heart Association, referred to ApoB as a stronger indicator of atherogenicity than LDL-cholesterol alone, and recommended measurement of ApoB for cardiovascular risk assessment, especially in those with elevated triglycerides

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