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Possible complications related to GLP-1 use under anesthesia include: Aspiration due to delayed gastric emptying Hemodynamic instability: pronounced hypotension or bradycardia Altered response to opioids and sedatives, requiring dose changes Perioperative hypoglycemia from additive glucose-lowering effects Nausea and vomiting increasing postoperative airway risk Delayed recovery of bowel function, affecting discharge timing Interference with regional anesthesia sympathetic block assessment Post-Surgery Restart Post-surgery restart of GLP-1 receptor agonists should be done with clear criteria and close coordination to avoid complications and maintain therapeutic goals

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BMI prior to surgery was 49.4 8.9 kg/m 2 (mean SD), total weight loss after surgery was 21.5 10.3% (mean SD), and maximum weight loss following BS was 29.1 11.9% (mean SD)

The comprehensive benefits of GLP-1 and GLP-2 make it a valuable asset in the therapeutic arsenal against Type 2 Diabetes, providing hope and improved quality of life to millions affected by this chronic condition