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Autophagy dysregulation is involved in the pathophysiology of DKD by increasing ROS production, mediating inflammatory responses and inducing renal cell damage and apoptosis (116, 117)

Sechi G, Deledda MG, Bua G, et al

Under stress, enhanced ABA biosynthesis promotes binding to the START domain of PYL proteins, inducing a conformational change that enables interaction with PP2Cs (Melcher et al

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