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Creatine supplementation helps maintain intramuscular energy stores (phosphocreatine), which supports continued muscle protein synthesis even when overall energy intake is reduced

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By boosting your levels in the morning, you are effectively "priming" your body's defense system for the challenges ahead

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doi:10.1006/bbrc.1993.2226

The Semaglutide Treatment Effect in People with Obesity (STEP) trials showed 12%-15% weight loss with semaglutide, less in type 2 diabetes patients