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Therapies with improved efficacy would ideally not come at the cost of compromised tolerability, especially considering that patient discontinuation due to AEs is an important factor in physician decision making in this space
Optimal doses of curcumin for cancer chemoprevention or therapeutic uses have not been established
Side effects tend to mirror those of GLP-1 agonists: Nausea Diarrhea Decreased appetite Possible gallbladder effects (as with all rapid weight loss) Minimal risk of hypoglycemia when used without insulin Importantly, GIP on its own does not cause hypoglycemia , making it a relatively safe therapeutic target
Lancet Diabetes Endocrinol, 7 ,
Lipoic acid inhibits expression of ICAM-1 and VCAM-1 by CNS endothelial cells and T cell migration into the spinal cord in experimental autoimmune encephalomyelitis
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