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Published studies have investigated NNMT and NNMT inhibitors across areas of laboratory and preclinical research, including NNMT influences multiple interconnected biochemical pathways

While clinical interactions have not been documented, combining multiple compounds that affect similar pathways increases unpredictability

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And some who supplement with it say they feel born again. Sounds pretty promising

Low Levels of Serum Total Vitamin B12 Are Associated with Worse Metabolic Phenotype in a Large Population of Children, Adolescents and Young Adults, from Underweight to Severe Obesity

There is growing evidence that the microbiome may be critical for establishing, maintaining, and reversing obesity 14,15,16 , and that both diet composition and adiposity each contribute to modulation of the mouse gut microbiome profile 49