Contact your GP if constipation persists despite over-the-counter treatment for 12 weeks, or if you experience severe abdominal pain, rectal bleeding, unexplained weight loss, or persistent vomiting, as these may indicate complications requiring further investigation
Severe fatigue can indicate medication intolerance or other medical issues requiring attention
1.4 Inflammation Molecules released from dead cells create an inflammatory microenvironment
Taking your dose 60 to 90 minutes before the event youre preparing for, rather than 30 minutes, is a reasonable adjustment for the first few weeks
Fix those three variables and the discomfort drops to near-zero for most people
However, they also impact specific parts of your brain that are wired to make you feel nauseous