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Galon et al., 2006)

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In the context of atherosclerosis and aging, there is a notable increase in inflammation and oxidative stress, in which high MT levels are associated with lower Zn availability

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We were therefore surprised to find that GSTP1 knockdown did not significantly influence cell growth rate or alter cell cycle progression in A2780 cells, although similar findings have been reported in a series of ovarian cancer cell lines made resistant to cisplatin, carboplatin and paclitaxel (Li et al, 2004), suggesting limitations of the use of immortalised cancer cell line models