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Breast Cancer Res Treat, 2012
The involvement of bombesin- like peptides in the pathogenesis of a wide range of human tumors, their function as autocrine/paracrine tumoral growth factors, and the high incidence of BN/GRP receptors in various human cancers prompted the design and synthesis of BN/ GRP receptor (GRPR) antagonists such as RC-3095, RC-3940-II, and RC-3950
Asparagine synthetase deficiency: new inborn errors of metabolism
June 3, 2017
542 The safety of mitochondrial transplantation was evaluated in a clinical trial that included 30 patients with myocardial infarction, in which participants in the treatment group accepted autologous platelet-derived mitochondria injections into the coronary arteries, and after 40 days, the treatment group had improvements in left ventricular ejection fraction and exercise capacity, but there were no significant differences in the occurrence of adverse events such as arrhythmias and fever between the treatment and control group
These ranges come from animal-data extrapolation and informal reports, not controlled human trials, and the two routes are not directly interchangeable
