semaglutide vs. phentermine vs for weight loss Semaglutide vs Phentermine?

When you take a drug, it needs to be absorbed into your bloodstream to be effective

This extended stay can lead to an increased risk of constipation as more water is absorbed from the waste, hardening the stool further

Crit Rev Food Sci Nutr (2014) 54:98114

GLP-1 medications mimic this hormone at higher, more consistent levels so you: Feel full sooner and stay satisfied longer Experience fewer cravings (especially for sugar and processed foods) Eat less without constant willpower battles Lose weight steadily over weeks and months Clinical studies show average weight loss of 1522% of body weight that's 3045+ pounds for someone starting at 200 lbs

However, the physiological half-life of GLP-1 in circulation is very short (less than 2 min), which can be attributed to both rapid proteolytic cleavage of the amide bond of alanine at position 8 (Ala8) in the N-terminus by ubiquitous dipeptidyl peptidase IV (DPP-IV), which results in the removal of the two N-terminal amino acids leading to the formation of a truncated inactive form 10,11 and clearance by the kidney as well

This hasnt been my personal experience, but it is something to keep in mind