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Wait until initial pain and inflammation decrease (typically week 2-3 of treatment) before beginning progressive loading protocols
After 8 weeks, improvement stalls
The process is almost entirely painless, nothing but a quick needle prick
The standard dosage for severe deficiency typically starts with 1 mg daily injections, transitioning to weekly and then monthly maintenance doses
Still very manageable
Some researchers use lower-dose maintenance protocols between cycles rather than complete cessation
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