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Several important considerations apply: Individuals with active or severe gastrointestinal disease may experience worsening symptoms due to the gastrointestinal side effects of GLP-1 medications The slowed gastric emptying caused by these drugs could theoretically exacerbate symptoms in people with strictures or obstructive complications of Crohn's disease Weight loss associated with GLP-1 therapy may be inappropriate in patients with Crohn's disease who are already experiencing malnutrition or unintentional weight loss The interaction between GLP-1 medications and the inflammatory processes in IBD is not fully understood Clinical decision-making should involve a thorough assessment of disease activity, nutritional status, presence of complications (such as strictures or fistulas), and the primary indication for GLP-1 therapy

Wiedau-Pazos M, Goto J, Rabizadeh S, Gralla E, Roe J, et al

Birth control pills might not work as well

Dispose of unused or expired product through a pharmacy take-back program or place in a sealed plastic bag mixed with coffee grounds before throwing it in household trash

If you have a procedure coming up, tell your anesthesia team you're on one of these medications

A central regulator of this epithelial barrier is the intestinal microbiota [21]