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However, metabolic tracing of 13 C-heptanoate indicates that propionyl-CoA predominantly produces glutamine, which indicates that astrocytic metabolism is responsible for the majority of this anaplerotic pathway (Marin-Valencia et al., 2013)

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To generate mice with inducible deletion of IGF1R in MSCs, we crossed Nestin-Cre ER transgenic mice with Igf1r fl/fl mice