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Acetaminophen metabolism directly depletes glutathione
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The clean reads were mapped to the rat reference genome GCF_000001895.5_Rnor_6.0, and the reference gene sequences were mapped using HISAT version 2.0.4 ( 3 ) becomes 3, the expression level of 128 (= 2 7 ) becomes 7, and so on)
Although any cells of the body can synthesize GSH, not every cell can take up intact GSH from the blood circulation
The observed effect was least pronounced in the BSO-treated group, as shown in western blot
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