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ClinicalTrials.gov (2026) 11

In the pancreas, GLP-1 receptor activation stimulates insulin secretion when blood glucose levels are elevated, whilst simultaneously suppressing glucagon release, thereby improving glycaemic control

Importantly, tirzepatide may reduce the effectiveness of oral hormonal contraceptives due to delayed gastric emptying

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Nitric oxide (NO) is a free radical gas molecule produced endogenously from L-arginine, oxygen, and NADPH by an enzyme nitric oxide synthase (NOS) [139]