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Spray tans (dihydroxyacetone-based) chemically oxidize amino acids in the stratum corneum to produce temporary brown pigment they do not involve melanin synthesis, provide zero UV protection, and fade within 57 days

The non-selectivity is both MT-2's strength (diverse pharmacology) and its weakness (unpredictable multi-system effects and increased side effect burden)

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Initial testing: Do CBC and B12 tests before starting treatment and again after the first dose

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