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GLP-1 medications are designed to mimic this hormone and help people with type 2 diabetes and obesity manage their blood sugar and weight more easily

GLP-1, binds to GLP-1R mostly in an -helix conformation with a large surface of contact with both the extra-cellular domain and the seven transmembrane domain 27,30

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These findings suggest that neither direct release of GLP-1 in the OB from hindbrain PPG neuron projections, nor volume transmission via release of GLP-1 into the ventricles are likely sources of GLP-1 to activate OB GLP-1R

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2014), affecting both the balance of hepatic free fatty acids and the expression of key lipid metabolism genes in the liver (Suciu et al