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In addition to impaired energy production, mitochondrial dysfunction can lead to direct damage to mitochondrial DNA (mtDNA) (91, 92)

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Glucose levels were then increased to 20 mM and cells imaged for a further 5 minutes, followed by mitochondrial hyperpolarisation using 20 g/mL oligomycin for 5 minutes and depolarisation using 20 M carbonyl cyanide 4-trifluoromethoxyphenylhydrazone (FCCP) for 5 minutes

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doi:10.3390/nu14194004 91

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