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If reduced doses of GLP-1 drugs prove viable for more people, the strategy may be a game-changer for obesity treatment

Rapid improvement in blood sugar control can sometimes temporarily worsen diabetic eye disease

The authors state it had never been reported with melanotan before

Galawesh T, Goljameen Midhat A, Ozdan G

1810): glucagon receptors also couple to Gi protein in human atrial myocytes, and Gi upregulation in the cardiomyocyte inhibits cAMP formation and Gs-coupled signal transduction, so glucagon action in the chronically failing heart "may theoretically be impaired." Two limits on how far that carries: the condition Petersen describes is heart failure , not obesity or sedentary metabolic dysfunction, and the impairment is offered as a hypothesis, not an observation

This puts you comfortably in the middle of the recommended 36 to 46 degree range with buffer on the warm side