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Effects of physicochemical properties and other factors on systemic nasal drug delivery
In two randomised controlled trials (RCT) in patients with coexisting ID anaemia and sub-clinical hypothyroidism, treatment with iron and L-T4 together was considerably more effective in improving iron status than was treatment with iron alone ( Reference Ravanbod, Asadipooya and Kalantarhormozi 60 , Reference Cinemre, Bilir and Gokosmanoglu 61 )
Also, they stimulate the endothelium to produce nitric oxide, reduce oxidative stress, and have antiatherogenic and antiinflammatory effects
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