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Most patients tolerate the combination well, but individual responses vary based on baseline kidney function, electrolyte status, and cardiovascular reserve

These hormones regulate appetite, insulin secretion, and blood sugar levels

10.1146/annurev-physiol-021115-105439 3

[Abstract] Biomater Res

Severe Skin Reactions : Rarely, Januvia may cause severe skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis, characterized by blistering, peeling, and severe skin pain