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Exposure per milligram is higher, particularly in lighter East Asian users, while the smaller fat reserve makes a 75:25 fat-to-lean split more consequential

PLoS One 6:e20267

Nervenarzt 78(1):4552 Allegaert K, van Mieghem T, Verbesselt R, de Hoon J, Rayyan M, Devlieger R et al (2009) Cefazolin pharmacokinetics in maternal plasma and amniotic fluid during pregnancy

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This opposing regulatory effect is due to the different tolerances of human and mouse cells to citric acid