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ADC linker technology Linkers are engineered chemical moieties that attach the cytotoxic payload to the antibody, with their design critically influencing both the stability of the ADC in systemic circulation and the efficiency and specificity of payload release at the target site 6,54

Simultaneously, cells exhibiting elevated BH4 levels can alleviate oxidative damage by reducing CoQ10

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Increased production of PAI-1 also leads to enhanced proinflammatory events via activation of monocyte adhesion to the vessel wall