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The selected genes and metabolites are listed in Table S4

1.12 Hashimotos thyroiditis and endogenous factors In addition to external exposures, inherent biological characteristicssuch as sex, hormonal changes, and physiological statesfurther shape the risk and clinical expression of HT

Heartburn Rare, but serious side effects may include: Acute pancreatitis (including fatal, hemorrhagic, necrotizing) Acute gallbladder disease Acute kidney injury (typically secondary to dehydration) Severe gastrointestinal disease / delayed gastric emptying Hypoglycemia (especially with insulin or sulfonylureas) Hypersensitivity reactions including anaphylaxis and angioedema Pulmonary aspiration during anesthesia or deep sedation (delayed gastric emptying) Suicidal behavior and ideation (monitor) Diabetic retinopathy complications (in T2D clients with pre-existing retinopathy) Thyroid C-cell tumors (rodent data)

10.1093/eurheartj/ehz486 19 DeNicolaM.DuJ.WangZ.YanoN.ZhangL.WangY.et al (2014)

158 Sesamol similarly promotes adipocyte browning and enhances lipid metabolism through mitophagy regulation