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A factual note on regulatory status: both semaglutide and tirzepatide are approved prescription drugs in various jurisdictions for clinical indications, but in the Canadian research-supply context they are sold strictly as research-grade compounds and are not approved by Health Canada for the research uses discussed here
Pyrimidinedione Analogs In 2018, Li et al
A milligram (mg) is a measure of weight or mass
The semaglutide without exercise guide explains what you are leaving on the table by skipping physical activity, and the difference in outcomes is substantial
Your TSH, free T3, and free T4 levels should be stable and in range before starting semaglutide or tirzepatide
Secondary outcomes showed semaglutide reduced myocardial infarction (HR 0.81) and stroke (HR 0.84) versus sitagliptin, while tirzepatide was non-inferior to dulaglutide for mortality, myocardial infarction, and stroke
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