Severe gastrointestinal adverse effects (persistent vomiting or diarrhoea) can lead to dehydration and, in susceptible individuals, acute kidney injury
Dietary and lifestyle factors Wegovy is most effective when used alongside a balanced diet with fewer calories and nutrient-rich foods
Hayaishi, J
These treatments can modify or bolster the bodys immune response, restore balance, and reduce the side effects commonly associated with oral medications, such as gastrointestinal discomfort
In a STEP 8 trial, adults with overweight or obesity (without diabetes) experienced greater weight loss with once-weekly semaglutide compared to once-daily liraglutide, alongside diet and exercise counseling
Free testosterone levels drop significantly during treatment, and these benefits often remain stable even after stopping GLP-1 therapy, provided metformin is continued