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Results from ESSENCE (NCT04822181), an ongoing global Phase 3 clinical trial showed subcutaneous semaglutide, given at 2.4 mg once weekly, promoted MASH resolution

With the highest dose (2.4 mg), people have been shown to lose an average of 15% of their body weight in about 2 years

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However, this correlation turned negative when the effects of PC-DHA and LPC-DHA are included, since the latter induce a much greater increase in brain DHA without a concomitant effect on erythrocytes (Fig

3/ This is the second positive RCT in a year