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GLP-1 receptor agonists can cause hypoglycaemia, but rates of symptomatic or spontaneously reported hypoglycaemia in clinical trials enrolling patients without diabetes (and thus not taking other hypoglycaemic medications) are low, typically between 1% and 5% [145]
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Standard titration versus conservative approach The standard tirzepatide titration starts at 2.5mg weekly for 4 weeks, then increases to 5mg, with subsequent increases to 7.5mg, 10mg, 12.5mg, and potentially 15mg at 4-week intervals
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The trials compared liraglutide, exenatide, or oral semaglutide with usual care
KPV has drawn attention for its anti-inflammatory properties, particularly its potential role in modulating NF-kappaB signaling
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