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So they literally can't function as they're supposed to

doi: 10.1016/j.jds.2024.07.009 38 ChiL.ChengX.LinL.YangT.SunJ.FengY.et al

Kumar P, Liu C, Hsu JW, Chacko S, Minard C, Jahoor F, et al

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Second, patients should be stratified by metabolic phenotype, including persistent hypoperfusion, inflammatory burden, BBB leakage, comorbid metabolic disease, and chronic network dysfunction