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These findings highlight an important metabolic trade-off, suggesting that excessive augmentation of cysteine or GSH pools may not always be beneficial and could limit the efficacy of antioxidant-based therapeutic strategies

Research found no evidence of tolerance development, receptor desensitization, or accumulating side effects over the study periods

doi: 10.1038/372425a0 22 LockeAEKahaliBBerndtSIJusticeAEPersTHDayFRet al

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Intestinal obstruction, fistulae, abdominal abscess, perianal disease, pyoderma gangrenosum, arthritis, and amyloidosis occur

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