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21 Several incretin-based therapies, including liraglutide, dulaglutide, semaglutide, and tirzepatide, are currently approved for patients with type 2 diabetes ( Table )
However, the authors stress that caution remains appropriate for a small, specific group
PMID: 63 JanikiewiczJ.SzymanskiJ.MalinskaD.Patalas-KrawczykP.MichalskaB.DuszynskiJ.et al
When Medication Adjustments May Help If reactions persist despite good technique, your clinician may recommend: Switching to a different formulation Changing injection frequency Exploring alternative formulations or supportive therapies Over-the-Counter Options That May Help If the steps above dont fully relieve symptoms, a few short-term, over-the-counter options can help calm mild injection site reactions: Hydrocortisone 1% cream applied once or twice daily for up to 3 days to reduce redness and inflammation Non-drowsy allergy medications such as loratadine (Claritin) or cetirizine (Zyrtec) to help with itching Cold compresses applied for 1015 minutes to reduce swelling and soothe irritation Fragrance-free moisturizer to support the skin barrier if dryness is contributing to irritation Topical anti-itch creams containing pramoxine or menthol for temporary itch relief A Reassuring Perspective Injection site reactions can feel frustrating, especially when everything else is going well
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