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Conditions that are related to mitochondrial dysfunction and reliant on FAD and FMN include Parkinsons disease, Alzheimers, migraines, Complex I deficiency, Alpers syndrome, multiple sclerosis, and Kearns Sayre syndrome.[ref] Nutrient interactions: Riboflavin also helps convert tryptophan to niacin (vitamin B3), which in turn activates vitamin B6 .[ref] It is also essential for the methylation cycle and folate-related metabolism

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Pineal volume reduction in patients with mild cognitive impairment who converted to Alzheimers disease