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Notably, the adverse effects caused by metformin therapy for adolescent patients with PCOS, especially gastrointestinal side effects, need to be a concern, as they may affect their quality of life and treatment adherence

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230,231 GLP-1 RAs have been previously described in this review as improving tissue homeostasis and repair through reducing age-related inflammation (i.e., TNF- and IL-6)

Growth hormone exerts an anti-catabolic effect during energy restriction, helping preserve lean mass. Jrgensen, J.O.L., Growth Hormone & IGF Research 3

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