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The VITALS trial randomly assigned 409 patients with clinically diagnosed Alzheimer disease (MMSE scores between 14 and 26) and normal vitamin B12, folate, and total homocysteine levels to daily B vitamin supplementation (B12 1 mg, B6 25 mg, folate 5 mg) or placebo, and followed the patients for 18 months (08)

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These claims are not supported by robust clinical evidence in healthy adults, and no large-scale human trials have validated this combination