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Fluctuations in the NAD + /NADH ratio regulate SIRT enzyme activity, thereby influencing nuclear genes involved in antioxidant defense, glycolipid metabolism, and mitochondrial homeostasis [232]
Acta Neurologica Scandinavica
Approximately 25-30% of patients on SSRIs experience weight gain over time, which can worsen body image concerns and reduce treatment adherence for both conditions
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The combination could produce additive or even synergistic improvements in these markers, which translates directly to reduced cardiovascular risk
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