One hypothesis is that we observed a greater induction of NRF2 through liver-specific Gclc deletion as compared to KEAP1 inhibition with CDDO-me because CDDO-me is a weaker inhibitor of NRF2-KEAP1 interaction compared to the ROS generated following GSH depletion
It is not available on NHS prescription and has not been evaluated by NICE for any clinical indication
If youre starting to notice the effects of agingwhether its brain fog, persistent fatigue, unwanted weight gain, or simply not recovering as quickly as beforewhat if I told you that the most potent strategy for looking and feeling younger, especially after 40, isnt solely reliant on lifestyle changes, cosmetic procedures, or surgery
PMID: 122 HarleyITWStankiewiczTEGilesDASofticSFlickLMCappellettiMet al
This also includes accounting for the positive impact of GLP-1s on heart disease
The choice of non-GMO sunflower-derived phosphatidylcholine over cheaper soy alternatives