That pathway is still there, and the moment the pharmaceutical effect is reduced, it reasserts itself
In the STEP 1 GLP-1 study, participants regained about two-thirds of prior weight loss within one year after stopping semaglutide, so it comes back fast
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Most of that is for on-label use to treat obesity, but more and more endos are prescribing them off-label because of the positive results for BG management
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This is likely because GLP-1 agonists can delay the emptying of bile from the gallbladder