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SURMOUNT-MAINTAIN (Horn 2026, 112 weeks): continued top dose -21.9% vs 5 mg step-down -16.6% vs placebo -9.9%, rescue therapy 8/25/67%: Aronne JAMA 2024
This high overall GI rate (while mostly mild) likely reflects the combined GI effects of activating both GLP-1 and amylin pathways simultaneously
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It does not: five dose groups of 100102 is roughly 506, and 506 + 99 + 101 = 706, which matches the registrys recorded enrolment of 706 exactly [6]
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