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Immunogenicity is a recognised consideration for engineered peptide analogues, and it is one of the things a research-grade vial of unverified purity cannot speak to at all impurities and aggregates are themselves immunogenic risk factors
Pickart L, Freedman JH, Loker WJ, Peisach J, Perkins CM, Stenkamp RE, Weinstein B
Therefore, use of rhEPO for treatment of tissue injury is limited by the potential side effects of increased erythrocyte mass and endothelial cell activation, which, in combination with activated platelet production, predisposes to thrombosis (6,7)
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