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The Annals of Pharmacotherapy

These include: Age and overall health status Severity of Vitamin B12 deficiency Presence of underlying medical conditions, such as gastrointestinal disorders Concurrent medications that may interact with Vitamin B12 For example, older adults or those with severe deficiencies might need more

Several formulation variables plausibly influence irritation: the concentration of the serum, the carrier and any preservatives, and how frequently it's applied

This is the foundation of scientific integrity and allows researchers to generate reliable and reproducible data for publication

[5] Causes [edit] Vitamin B 12 cannot be produced by the human body, and must be obtained from the diet

That said, the compound has not been through full Phase III trials or FDA drug approval