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Treat patients as higher risk for aspiration if symptoms, missed hold, or urgent procedures
Advocacy groups including Obesity Canada have submitted cost-effectiveness reanalyses using 2024-2026 real-world data showing larger cardiovascular benefits than the original trials (Sharma et al., Canadian Medical Association Journal, 2025)
Ipamorelin was investigated in a Phase II trial for postoperative ileus but did not meet its primary endpoint, and development was discontinued
Pregnancy Safety Registries: Ongoing pharmacovigilance and pregnancy exposure registries are necessary to define teratogenic risk and optimal discontinuation intervals
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3D), and exercise tolerance (Fig
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