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Tryptophan was found to reduce wakefulness after sleep onset and increase sleep efficiency as measured with actigraphy in all participants and improve subjective sleep quality scores in those carrying the genetic variant of interest

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A medication that is pharmacologically appropriate may still fail clinically if it increases reactivity

PMID 1460582

Both in human and horse e-GSTs, many oxidizing chemicals may induce the formation of an intra-chain disulfide involving the two highly reactive cysteines, that is, Cys47 and Cys101