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Briefly, ATDC5 cells were treated twice with 0.1 M Dox (48 h treatment interval), and senescent chondrocytes were established after 4 days of stimulation
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Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity
In the lipids and lipid-like molecules and nucleosides, nucleotides and analogs, the metabolites with the greatest increase were glutarate semialdehyde and deoxyuridine, while the metabolites with the greatest decrease were heptanoic acid and nicotinic acid mononucleotide, respectively (Additional file 4: Figure S4, Additional file 5: Fig
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