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It is non-addictive and preserves the complete physiology of the sleep-wake cycle
While (-)-7- iso -jasmonic acid is the main isomer isolated from plant tissues and was long thought to be the key metabolite, it is now recognized that (+)7 iso -jasmonic acid or cis -( epi )-jasmonic acid is in fact the active isomer
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The lower activity of ChaC2 may be partly attributed to flexible loop 2, acting as a gating function to achieve specificity for GSH binding and regulate a constant GSH degradation rate
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