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3b), suggesting increased oxidative stress
As of January 2025, efgartigimod is the only FcRn antagonist with registered (albeit in not all cases ongoing) trials within bullous pemphigoid, post-coronavirus disease 2019 (COVID-19) postural orthostatic tachycardia syndrome, membranous nephropathy, and antineutrophil cytoplasmic antibody-associated vasculitis, and disclosed development plans detail an investigation of efgartigimod within more than ten indications [245]
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In addition, a recent study has identified a novel variant (rs143276236) in the gene ARFGEF3 in the discovery cohort with a potential to reduce HbA1c in individuals with metformin monotherapy in African-Americans, although this find was not significant in the validation cohort (Wu et al., 2023)
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