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Fat-soluble vitamins require the presence of dietary fat to stimulate the release of bile acids, which are necessary for their emulsification and absorption in the small intestine
Soon after this, in 1788, Thomas Crawley, another English physician, suggested on the basis of one of his clinical cases that diabetes might be linked to damage to the pancreas
As a condition of accelerated approval, further studies are required to confirm clinical benefit of ipilimumab and nivolumab for this indication
PLoS One 3 , e2935 (2008)
This FAO shift increased the activity of immunosuppressive enzymes and promoted the generation of regulatory T cells, leading to tumor-mediated immune tolerance
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