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If selenium concentration reaches or exceeds 122 g/l in plasma, as in the top tertile of the Nutritional Prevention of Cancer trial ( Reference Duffield-Lillico, Reid and Turnbull 109 ) or is already 137 g/l in serum, as in SELECT ( Reference Lippman, Klein and Goodman 106 ) , supplementation should be avoided ( Reference Lippman, Klein and Goodman 106 Reference Stranges, Marshall and Natarajan 108 , Reference Kristal, Darke and Morris 110 )
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Reduced methylation causes a reduction in the transfer of the sulphur from homocysteine into the sulphation cycle, leading to lower intracellular cysteine, and reduced production of glutathione
This has not been examined in subgroup analyses
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