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New England Journal of Medicine , 389(6), 514-526
They reduce the activity of key enzymes like IDO and TDO, promoting neuroprotection and mitigating excitotoxicity and inflammatory damage
AOD 9604 has an extended half-life reaching 8-10 hrs and is taken once a day, either in the morning or evening
Induction of bim limits cytokine-mediated prolonged survival of neutrophils
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7), we emphasize that the ICV component served primarily as a preclinical proof-of-concept to validate direct CNS engagement for neural repair
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